DVT is among the performance in which irregular hemorheology and you may viscosity cause ischemia and you can anoxia of areas (11–13)
Blood clots is because of bloodstream solidification and you will unusual viscosity on account of obstacles impacting their fluidity; it leads to the forming of thrombocytes and you will activation off blood coagulation basis (8–10). Hence, correcting blood viscosity and you will improving blood coagulation means indexes has actually a keen crucial part regarding the cures and you may remedy for DVT.
Our very own analysis indicated that for three days and ten months after DVT modeling, hemorheology and you will coagulation indexes was in fact an educated regarding high-amount folic acid and you can supplement B12 category. Certain accounts provides proposed you to definitely Hcy try good blood clots-building broker, and you may highest Hcy you certainly will create strong venous thrombosis colombian cupid (14–17). At the same time, plasma D-dimer could have been advised for good forewarning mode for thrombus and you may hypercoagulable condition (18,19). 10 weeks once DVT modeling, we unearthed that the degree out of Hcy and you may D-dimer enhanced more regarding the higher-dose classification.
Because of histopathologic test, i discovered that 10 months immediately after DVT acting this new highest-serving and reasonable-amount groups presented significant change in the change off down extremity deep venous thrombosis. Strong venous thrombosis out of all the way down extremity having color Doppler ultrasound diagnosis has some positives, particularly effortless procedure, safeguards and you will energy conserving, inexpensive, repeatability and you will lead observance, plus the recognition out-of related sores and hemorrhaging provides around bloodstream ships (20). Our abilities in addition to indicated that immediately after DVT acting, brand new energetic price out-of down extremity strong venous thrombosis treatment of high-dosage group is actually one hundred%. The outcomes of color Doppler ultrasound medical diagnosis from DVT corresponded to help you the results within the histopathologic examination. This verified the newest feasibility and you may energy conserving away from color Doppler ultrasound prognosis getting deep venous thrombosis of one’s down extremity.
In the sumin B12 features clear therapeutic consequences inside the a bunny design out-of DVT that have hyperhomocysteinemia. The latest higher-dosage we tried improved certain related episodes, for instance the levels of Hcy and you can D-dimer, hemorheology, coagulation mode, and you will vein cystic. Overall, this research contain the entry to highest doses from folic acidic and you may supplement B12 to relieve DVT.
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